To mimic the structure of breast tumor microenvironment, novel double-network poly (N ɛ-
acryloyl l-lysine)/hyaluronic acid (pLysAAm/HA) hydrogels were fabricated by a two-step …

In tumor biology, it is widely recognized that 3D rather than 2D cell culture can recapitulate
key features of solid tumors, including cell-extracellular matrix (ECM) interactions. In this …

Abstract 2D cell culture is widely utilized to develop anti-cancer drugs and to explore the
mechanisms of cancer tumorigenesis and development. However, the findings obtained …

The development of three-dimensional (3D) culture models is promising for cancer biology
studies and the discovery of new anticancer drugs because they mimic the in vivo situation …

Extracellular matrix regulates hallmark features of cancer through biochemical and
mechanical signals, although mechanistic understanding of these processes remains limited …

Abstract Tissue‐engineered three‐dimensional (3D) cancer models employing biomimetic
hydrogels as cellular scaffolds provide contextual in vitro recapitulation of the native tumor …

Background Breast cancer negatively affects women's health worldwide. The tumour
microenvironment plays a critical role in tumour initiation, proliferation, and metastasis …

Polysaccharide hydrogels are promising candidate matrices for recapitulating the
characteristics of extracellular matrix (ECM) in breast tumors in terms of their structure and …

Breast cancer is the most common cancer among women, and even though treatments are
available, efficiency varies with the patients. In vitro 2D models are commonly used to …

Abstract Three‐dimensional (3D) biomimetic cell culture platforms offer more realistic
microenvironments that cells naturally experience in vivo. We developed a tunable …