Impacts of genome-wide analyses on our understanding of human herpesvirus diversity and evolution
Until fairly recently, genome-wide evolutionary dynamics and within-host diversity were
more commonly examined in the context of small viruses than in the context of large double …
more commonly examined in the context of small viruses than in the context of large double …
Alphaherpesvirus genomics: past, present and future
Alphaherpesviruses, as large double-stranded DNA viruses, were long considered to be
genetically stable and to exist in a homogeneous state. Recently, the proliferation of high …
genetically stable and to exist in a homogeneous state. Recently, the proliferation of high …
Rapid genome assembly and comparison decode intrastrain variation in human alphaherpesviruses
LR Parsons, YR Tafuri, JT Shreve, CD Bowen… - MBio, 2015 - Am Soc Microbiol
Herpes simplex virus (HSV) is a widespread pathogen that causes epithelial lesions with
recurrent disease that manifests over a lifetime. The lifelong aspect of infection results from …
recurrent disease that manifests over a lifetime. The lifelong aspect of infection results from …
[HTML][HTML] Comprehensive annotations of human herpesvirus 6A and 6B genomes reveal novel and conserved genomic features
Y Finkel, D Schmiedel, J Tai-Schmiedel, A Nachshon… - Elife, 2020 - elifesciences.org
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the
majority of the human population. They encompass large genomes and our understanding …
majority of the human population. They encompass large genomes and our understanding …
Herpes virus replication
P Boehmer, A Nimonkar - IUBMB life, 2003 - Wiley Online Library
Herpesviruses are large double stranded DNA animal viruses with the distinguishing ability
to establish latent, life‐long infections. To date, eight human herpesviruses that exhibit …
to establish latent, life‐long infections. To date, eight human herpesviruses that exhibit …
Divergence and genotyping of human α-herpesviruses: an overview
P Norberg - Infection, Genetics and Evolution, 2010 - Elsevier
Herpesviruses are large DNA viruses that are highly disseminated among animals. Of the
eight herpesviruses identified in humans, three are classified into the α-herpesvirus …
eight herpesviruses identified in humans, three are classified into the α-herpesvirus …
[HTML][HTML] Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes
High throughout sequencing has provided an unprecedented view of the circulating diversity
of all classes of human herpesviruses. For herpes simplex virus 1 (HSV-1), we and others …
of all classes of human herpesviruses. For herpes simplex virus 1 (HSV-1), we and others …
[HTML][HTML] Specific capture and whole-genome sequencing of viruses from clinical samples
Whole genome sequencing of viruses directly from clinical samples is integral for
understanding the genetics of host-virus interactions. Here, we report the use of sample …
understanding the genetics of host-virus interactions. Here, we report the use of sample …
Evolution and diversity in human herpes simplex virus genomes
ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …
Genome sequencing and analysis of geographically diverse clinical isolates of herpes simplex virus 2
ABSTRACT Herpes simplex virus 2 (HSV-2), the principal causative agent of recurrent
genital herpes, is a highly prevalent viral infection worldwide. Limited information is …
genital herpes, is a highly prevalent viral infection worldwide. Limited information is …