A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection

CS Nelson, BC Herold, SR Permar - NPJ vaccines, 2018 - nature.com
Human cytomegalovirus (HCMV), a member of the beta-herpesvirus family, is the most
common cause of congenital infection worldwide as well as an important cause of morbidity …

Vaccine strategies against human cytomegalovirus infection

J Zhong, R Khanna - Expert Review of Anti-Infective Therapy, 2007 - Taylor & Francis
Human cytomegalovirus (HCMV) disease is a major cause of morbidity and mortality in
neonates and immunocompromised populations, such as transplant recipients and HIV …

Prospects of a vaccine for the prevention of congenital cytomegalovirus disease

B Plachter - Medical microbiology and immunology, 2016 - Springer
Congenital human cytomegalovirus (HCMV) infection is one leading cause of childhood
disabilities. Prevention of congenital HCMV disease by vaccination has consequently been …

Cytomegalovirus vaccines: current status and future prospects

KM Anderholm, CJ Bierle, MR Schleiss - Drugs, 2016 - Springer
Congenital human cytomegalovirus (HCMV) infection can result in severe and permanent
neurological injury in newborns, and vaccine development is accordingly a major public …

Development of a vaccine against human cytomegalovirus: advances, barriers, and implications for the clinical practice

S Scarpini, F Morigi, L Betti, A Dondi, C Biagi, M Lanari - Vaccines, 2021 - mdpi.com
Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection
in the post-rubella era, representing a major public health concern. Although most cases are …

Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease

TM Fu, Z An, D Wang - Vaccine, 2014 - Elsevier
Congenital infection of human cytomegalovirus (HCMV) is the leading cause of childhood
hearing loss and mental retardation. Unfortunately, a preventive vaccine remains elusive …

Update on the current status of cytomegalovirus vaccines

H Sung, MR Schleiss - Expert review of vaccines, 2010 - Taylor & Francis
Human cytomegalovirus (HCMV) is ubiquitous in all populations, and is the most commonly
recognized cause of congenital viral infection in developed countries. On the basis of the …

Lessons from acquired natural immunity and clinical trials to inform next-generation human cytomegalovirus vaccine development

X Hu, HY Wang, CE Otero, JA Jenks… - Annual review of …, 2022 - annualreviews.org
Human cytomegalovirus (HCMV) infection, the most common cause of congenital disease
globally, affecting an estimated 1 million newborns annually, can result in lifelong sequelae …

[PDF][PDF] Progress in cytomegalovirus vaccine development

M Schleiss - HERPES-CAMBRIDGE-, 2005 - researchgate.net
Cytomegalovirus (CMV) causes considerable morbidity and disability in infants who acquire
the infection in utero. Despite potent antiviral therapies, CMV also continues to be a major …

Advancing our understanding of protective maternal immunity as a guide for development of vaccines to reduce congenital cytomegalovirus infections

SR Permar, MR Schleiss, SA Plotkin - Journal of virology, 2018 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is the most common congenitally transmitted pathogen
worldwide, impacting an estimated 1 million newborns annually. Congenital HCMV (cCMV) …