Significant genetic variability exists between strains of murine cytomegalovirus (MCMV),
which can have profound impacts on the function of immunomodulatory genes. Analysis of a …

Infections with cytomegaloviruses are characterized by an intricate balance between the
expression of immunomodulatory viral proteins and antiviral immune defence. For human …

Murine cytomegalovirus (MCMV) expresses in excess of 170 open reading frames (ORFs),
many of which have unknown function. In addition, MCMV and other cytomegaloviruses …

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that encodes many proteins to
modulate the host immune response. Extensive efforts have led to the elucidation of multiple …

Murine cytomegalovirus (MCMV) is a widely used model for human cytomegalovirus
(HCMV) and has facilitated many important discoveries about the biology of CMVs. Most of …

Abstract CD8+ and CD4+ T lymphocytes are important in controlling human CMV (HCMV)
infection, but the virus has evolved protean mechanisms to inhibit MHC-based Ag …

The study of 'molecular mimicry'or 'genetic piracy', with respect to the utilisation of cellular
genes captured and modified during the course of virus evolution, has been an area of …

Cytomegaloviruses (CMVs) are host species-specific and have adapted to their respective
mammalian hosts during co-evolution. Host-adaptation is reflected by “private genes” that …

Cytomegalovirus (CMV) has yielded many insights into immune escape mechanisms. Both
human and mouse CMV encode a diverse array of gene products, many of which appear to …

Cytomegalovirus (CMV) remains a major human pathogen causing significant morbidity and
mortality in immunosuppressed or immunoimmature individuals. Although significant …