Human cytomegalovirus (HCMV) is under constant selective pressure from the immune
system in vivo. Study of HCMV genes that have been lost in the absence of, or genetically …

Natural killer (NK) cells are lymphocytes of the innate immune system capable of killing
hazardous cells, including virally infected cells. NK cell-mediated killing is triggered by …

Natural killer (NK) cells mediate innate immune responses against hazardous cells and are
particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK …

Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is
under intense, continuous selective pressure from the immune system. A key aspect of …

The outcome of mouse CMV (MCMV) infection varies among different inbred mouse strains
depending on NK cell effector functions governed through recognition receptor triggering …

A highly attractive approach to investigate the influence and hierarchical organization of viral
proteins on cellular immune responses is to employ mutant viruses carrying deletions of …

Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without
prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of …

Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression
of major histocompatibility complex (MHC) class I and II molecules on the surfaces of …

Human cytomegalovirus (HCMV) infection is a paradigm of the complexity reached by host-
pathogen interactions. To avoid recognition by cytotoxic T lymphocytes (CTL) HCMV inhibits …

Human CMV (HCMV) encodes multiple genes that control NK cell activation and cytotoxicity.
Some of these HCMV-encoded gene products modulate NK cell activity as ligands …