Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic
insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral …

Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic
insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral …

Uracil DNA glycosylases (UNG) are highly conserved proteins that preserve DNA fidelity by
catalyzing the removal of mutagenic uracils. All herpesviruses encode a viral UNG (vUNG) …

Herpesviruses are large double-stranded DNA viruses that encode core replication proteins
and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil …

Uracil DNA glycosylase (UNG) removes mutagenic uracil base from DNA to initiate base
excision repair (BER). The result is an abasic site (AP site) that is further processed by the …

Vast evolutionary distances separate the known herpesviruses, adapted to colonise
specialised cells in predominantly vertebrate hosts. Nevertheless, the distinct herpesvirus …

Cytosine deamination and the misincorporation of 2′-dUrd into DNA during replication
result in the presence of uracil in DNA. Uracil-DNA glycosylases (UDGs) initiate the excision …

Uracil DNA glycosylase (UNG) functions as a DNA repair or proofreading enzyme. The UNG
gene is present in nearly all prokaryotes and eukaryotes screened to date and is found in …

Uracil-DNA glycosylase encoded in many species functions as a DNA repair enzyme that
removes uracil residues from DNA. To investigate the potential function of uracil-DNA …

Herpes simplex virus-1 (HSV-1) is a large dsDNA virus that encodes its own DNA replication
machinery and other enzymes involved in DNA transactions. We recently reported that the …