Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
Follicle stimulating hormone (FSH) is an essential glycoprotein hormone for human
reproduction, which functions are mediated by a G protein-coupled receptor, FSHR …
reproduction, which functions are mediated by a G protein-coupled receptor, FSHR …
Structural Insights into Molecular Recognition and Receptor Activation in Chemokine–Chemokine Receptor Complexes
L Urvas, E Kellenberger - Journal of Medicinal Chemistry, 2023 - ACS Publications
The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …
after target for drug candidates. The number of experimental structures of chemokines in …
Cryo-EM structures of orphan GPR21 signaling complexes
X Lin, B Chen, Y Wu, Y Han, A Qi, J Wang… - Nature …, 2023 - nature.com
GPR21 is a class-A orphan G protein-coupled receptor (GPCR) and a potential therapeutic
target for type 2 diabetes and other metabolic disorders. This receptor shows high basal …
target for type 2 diabetes and other metabolic disorders. This receptor shows high basal …
Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family
Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory
signaling, are challenging because of their low surface expression in heterologous cells …
signaling, are challenging because of their low surface expression in heterologous cells …
Structural basis of peptide recognition and activation of endothelin receptors
Y Ji, J Duan, Q Yuan, X He, G Yang, S Zhu… - Nature …, 2023 - nature.com
Endothelin system comprises three endogenous 21-amino-acid peptide ligands endothelin-
1,-2, and-3 (ET-1/2/3), and two G protein-coupled receptor (GPCR) subtypes—endothelin …
1,-2, and-3 (ET-1/2/3), and two G protein-coupled receptor (GPCR) subtypes—endothelin …
Structural basis of agonist specificity of α1A-adrenergic receptor
Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and
nervous systems where they regulate blood pressure, cognition, and metabolism. However …
nervous systems where they regulate blood pressure, cognition, and metabolism. However …
Allosteric modulation of G protein-coupled receptor signaling
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins,
regulate a wide array of physiological processes in response to extracellular signals …
regulate a wide array of physiological processes in response to extracellular signals …
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …
Identifying treatment targets is challenging because the diseases are resulting from …
Pro-phagocytic function and structural basis of GPR84 signaling
GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by
endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro …
endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro …
Structural insights into the human niacin receptor HCA2-Gi signalling complex
The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for
dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated …
dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated …