GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro …
M Suzuki, S Takaishi, M Nagasaki, Y Onozawa… - Journal of Biological …, 2013 - ASBMB
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids (MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that …
VB Luscombe, D Lucy, CJR Bataille… - DNA and Cell …, 2020 - liebertpub.com
GPR84 is an inflammation-induced receptor highly expressed on immune cells, yet its endogenous ligand is still unknown. This makes any interpretation of its physiological …
M Sundqvist, K Christenson, A Holdfeldt, M Gabl… - … et Biophysica Acta (BBA …, 2018 - Elsevier
GPR84 is a recently de-orphanized member of the G-protein coupled receptor (GPCR) family recognizing medium chain fatty acids, and has been suggested to play important roles …
The orphan G protein-coupled receptor (GPCR) GPR84 is expressed on immune cells mediating proinflammatory and immunostimulatory effects. In this study, we prepared the …
J Lu, N Byrne, J Wang, G Bricogne, FK Brown… - Nature structural & …, 2017 - nature.com
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor 1 GPR40 enhance glucose-dependent insulin secretion and represent a potential …
Q Zhang, H Yang, J Li, X Xie - Journal of Pharmacology and Experimental …, 2016 - ASPET
G protein-coupled receptor 84 (GPR84) is a free fatty acid receptor activated by medium- chain free fatty acids with 9–14 carbons. It is expressed mainly in the immune-related …
The past decade has seen great progress in the understanding of the molecular pharmacology, physiological function and therapeutic potential of G-protein-coupled …
T Izume, R Kawahara, A Uwamizu, L Chen… - Nature …, 2024 - nature.com
GPR34 is a recently identified G-protein coupled receptor, which has an immunomodulatory role and recognizes lysophosphatidylserine (LysoPS) as a putative ligand. Here, we report …