Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

H Liu, Q Zhang, X He, M Jiang, S Wang, X Yan… - nature …, 2023 - nature.com
GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …

Pro-phagocytic function and structural basis of GPR84 signaling

X Zhang, Y Wang, S Supekar, X Cao, J Zhou… - Nature …, 2023 - nature.com
GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by
endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro …

Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor

M Suzuki, S Takaishi, M Nagasaki, Y Onozawa… - Journal of Biological …, 2013 - ASBMB
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids
(MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that …

20 years an orphan: is GPR84 a plausible medium-chain fatty acid-sensing receptor?

VB Luscombe, D Lucy, CJR Bataille… - DNA and Cell …, 2020 - liebertpub.com
GPR84 is an inflammation-induced receptor highly expressed on immune cells, yet its
endogenous ligand is still unknown. This makes any interpretation of its physiological …

[HTML][HTML] Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the …

M Sundqvist, K Christenson, A Holdfeldt, M Gabl… - … et Biophysica Acta (BBA …, 2018 - Elsevier
GPR84 is a recently de-orphanized member of the G-protein coupled receptor (GPCR)
family recognizing medium chain fatty acids, and has been suggested to play important roles …

An agonist radioligand for the proinflammatory lipid-activated G protein-coupled receptor GPR84 providing structural insights

M Köse, T Pillaiyar, V Namasivayam… - Journal of medicinal …, 2019 - ACS Publications
The orphan G protein-coupled receptor (GPCR) GPR84 is expressed on immune cells
mediating proinflammatory and immunostimulatory effects. In this study, we prepared the …

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

J Lu, N Byrne, J Wang, G Bricogne, FK Brown… - Nature structural & …, 2017 - nature.com
Clinical studies indicate that partial agonists of the G-protein-coupled, free fatty acid receptor
1 GPR40 enhance glucose-dependent insulin secretion and represent a potential …

Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein–coupled receptor 84

Q Zhang, H Yang, J Li, X Xie - Journal of Pharmacology and Experimental …, 2016 - ASPET
G protein-coupled receptor 84 (GPR84) is a free fatty acid receptor activated by medium-
chain free fatty acids with 9–14 carbons. It is expressed mainly in the immune-related …

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

S Talukdar, JM Olefsky, O Osborn - Trends in pharmacological sciences, 2011 - cell.com
The past decade has seen great progress in the understanding of the molecular
pharmacology, physiological function and therapeutic potential of G-protein-coupled …

Structural basis for lysophosphatidylserine recognition by GPR34

T Izume, R Kawahara, A Uwamizu, L Chen… - Nature …, 2024 - nature.com
GPR34 is a recently identified G-protein coupled receptor, which has an immunomodulatory
role and recognizes lysophosphatidylserine (LysoPS) as a putative ligand. Here, we report …