Representing the most attractive and successful druggable receptors of the proteome,
GPCRs regulate a myriad of physiological and pathophysiological functions. Although over …

G protein–coupled receptors (GPCRs) are essential mediators of cellular signaling and are
important targets of drug action. Of the approximately 350 nonolfactory human GPCRs, more …

G-protein-coupled receptors (GPCRs), also known as seven transmembrane receptors, are
the largest family of cell surface receptors in eukaryotes. There are∼ 800 GPCRs in human …

G-protein-coupled receptors (GPCRs) mediate many important physiological functions and
are considered as one of the most successful therapeutic targets for a broad spectrum of …

G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded
in the human genome, but progress in understanding and targeting them is hindered by the …

The ability of individual G protein-coupled receptors (GPCR) to engage multiple signaling
pathways opens opportunities for the development of better drugs. This requires new …

G-protein-coupled receptors (GPCRs) are a family of cell surface proteins that can sense a
variety of extracellular stimuli and mediate multiple signaling transduction pathways …

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …

The recognition that individual GPCRs can activate multiple signaling pathways has raised
the possibility of developing drugs selectively targeting therapeutically relevant ones. This …

G protein–coupled receptors (GPCRs), the largest family of signaling membrane proteins,
are the target of more than 30% of the drugs on the market. Recently, it has become clear …