Aging of humans is associated with functional alterations at all levels of the reproductive axis
and affects both steroidogenic and spermatogenic compartments. Unlike female …

For centuries, the importance of the testes for the maintenance of male phenotype,
psychosexual behavior, and physical power has been recognized. Indeed, testicular extracts …

In male mammals, changes at all levels of the hypothalamic-pituitary-testicular axis,
including alterations in the GnRH pulse generator, gonadotropin secretion, and testicular …

In contrast with women, who experience a complete and abrupt cessation of ovarian function
during the menopause, aging men largely maintain their testicular androgen production …

This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

Long-standing beliefs have associated aging in men with declines in sexual performance,
sex steroid serum levels, and fertility. Critical analysis of recent data, however, indicates that …

Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain,
fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone …

No discrete event marks a transition to male reproductive senescence; however, a number
of investigations have suggested that male fertility and reproductive hormone secretion …

Reproductive aging in the male occurs in a more subtle and gradual manner than is
observed in females. In humans, there are recordings of individuals in their seventh decade …

IN CONTRAST to the situation in women, where the menopause marks the end of the fertile
period, in men fertility persists into old age. Nevertheless old age in men is accompanied by …