[HTML][HTML] Virus-like particles: Revolutionary platforms for developing vaccines against emerging infectious diseases

H Tariq, S Batool, S Asif, M Ali, BH Abbasi - Frontiers in microbiology, 2022 - frontiersin.org
Virus-like particles (VLPs) are nanostructures that possess diverse applications in
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …

Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

[HTML][HTML] Virus-like nanoparticles as a theranostic platform for cancer

KR Kim, AS Lee, SM Kim, HR Heo… - … in Bioengineering and …, 2023 - frontiersin.org
Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral
structures through the hierarchical assembly of viral coat proteins, while lacking viral …

Engineered protein nanocages for concurrent RNA and protein packaging in vivo

S Kwon, TW Giessen - ACS synthetic biology, 2022 - ACS Publications
Protein nanocages have emerged as an important engineering platform for biotechnological
and biomedical applications. Among naturally occurring protein cages, encapsulin …

Protein-based delivery systems for RNA delivery

H Zhu, H Luo, R Chang, Y Yang, D Liu, Y Ji… - Journal of Controlled …, 2023 - Elsevier
RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …

[HTML][HTML] Uses and challenges of antiviral polyclonal and monoclonal antibody therapies

EB Struble, JMO Rawson, T Stantchev, D Scott… - Pharmaceutics, 2023 - mdpi.com
Viral diseases represent a major public health concerns and ever-present risks for
developing into future pandemics. Antiviral antibody therapeutics, either alone or in …

Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury

T Liu, Q Yang, H Zheng, H Jia, Y He, X Zhang, J Zheng… - Biomaterials, 2021 - Elsevier
Radiation‐induced lung injury (RILI) is a potentially fatal and dose-limiting complication of
thoracic cancer radiotherapy. However, effective therapeutic agents for this condition are …

[HTML][HTML] Assembly of protein cages for drug delivery

X Yu, Z Weng, Z Zhao, J Xu, Z Qi, J Liu - Pharmaceutics, 2022 - mdpi.com
Nanoparticles (NPs) have been widely used as target delivery vehicles for therapeutic
goods; however, compared with inorganic and organic nanomaterials, protein …

[HTML][HTML] An efficient and scalable method for the production of immunogenic SARS-CoV-2 virus-like particles (VLP) from a mammalian suspension cell line

S Hirschberg, F Ghazaani, G Ben Amor, M Pydde… - Vaccines, 2023 - mdpi.com
The rapid evolution of new SARS-CoV-2 variants poses a continuing threat to human health.
Vaccination has become the primary therapeutic intervention. The goal of the current work …

Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

S Zanganeh, M Doroudian, ZR Nowzari… - Advanced …, 2023 - Wiley Online Library
The rapid advancement of nanotechnology in recent years has opened new avenues of
investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant …