Pharmacological interventions in labor and delivery

S Wray, S Arrowsmith, A Sharp - Annual Review of …, 2023 - annualreviews.org
While there is not a wide range of pregnancy-specific drugs, there are some very specific
high-risk areas of obstetric care for which unique pharmacological approaches have been …

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

BM Arman, NK Binder, N de Alwis… - …, 2023 - rep.bioscientifica.com
In brief Preterm birth is the leading cause of perinatal morbidity and mortality; however,
current therapies offer limited efficacy to delay birth and improve neonatal outcomes. This …

[HTML][HTML] The contribution of racism-related stress and adversity to disparities in birth outcomes: evidence and research recommendations

SR Liu, LM Glynn - F&S Reports, 2022 - Elsevier
Highlights•Historical and ongoing racism has created conditions wherein women of color
are disproportionately exposed to stress and adversity.•The consequences of exposure to …

CCL21/CCR7 axis as a therapeutic target for autoimmune diseases

L Han, L Zhang - International Immunopharmacology, 2023 - Elsevier
Abstract Chemokine receptor 7 (CCR7) is a G protein-coupled receptor containing 7
transmembrane domains that is expressed on various cells, such as naive T/B cells, central …

[HTML][HTML] Tocolytic treatment for the prevention of preterm birth from a Taiwanese perspective: a survey of Taiwanese obstetric specialists

HH Lee, CC Yeh, ST Yang, CH Liu, YJ Chen… - International journal of …, 2022 - mdpi.com
IJERPH | Free Full-Text | Tocolytic Treatment for the Prevention of Preterm Birth from a
Taiwanese Perspective: A Survey of Taiwanese Obstetric Specialists Next Article in Journal …

Progesterone control of myometrial contractility

O Shynlova, L Nadeem, S Lye - The Journal of Steroid Biochemistry and …, 2023 - Elsevier
During pregnancy, the primary function of the uterus is to be quiescent and not contract,
which allows the growing fetus to develop and mature. A uterine muscle layer, myometrium …

Pharmacodynamic characterization of rytvela, a novel allosteric anti-inflammatory therapeutic, to prevent preterm birth and improve fetal and neonatal outcomes

T Habelrih, DÉ Tremblay, E Di Battista, X Hou… - American journal of …, 2023 - Elsevier
Background Preterm birth is the leading cause of neonatal morbidity and mortality. Studies
have shown that interleukin 1 plays a major role in the pathophysiology of preterm birth by …

Activity restriction for women with arrested preterm labor: a randomized controlled trial

G Saccone, L Della Corte, L Cuomo… - American Journal of …, 2023 - Elsevier
BACKGROUND In the past, some pregnant women have been recommended to be in
activity restriction because of the presumed increased risk of preterm birth due to the …

Metabolomic profiling of preterm birth in pregnant women living with HIV

NH Tobin, A Murphy, F Li, SS Brummel, MG Fowler… - Metabolomics, 2023 - Springer
Background Preterm birth is a leading cause of death in children under the age of five. The
risk of preterm birth is increased by maternal HIV infection as well as by certain antiretroviral …

Social isolation stress modulates pregnancy outcomes and the inflammatory profile of rat uterus

NA Lopes, EA Falkenberg, C Wiley, V Patel… - International Journal of …, 2022 - mdpi.com
Prenatal stressors have been linked to adverse pregnancy outcomes; including preterm birth
(PTB). Recent work demonstrates that social isolation in mothers represents a silent stressor …