Mitochondria-associated endoplasmic reticulum membrane (MAM) is a structural link
between mitochondria and endoplasmic reticulum (ER). MAM regulates Ca2+ transport from …

Metabolic diseases are associated with nutrient excess and metabolic inflexibility.
Mitochondria and endoplasmic reticulum are important organelles and nutrient sensors, and …

Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert
similar metabolic effects in different organs. Here, we establish a model where autophagy …

γ-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of
biological activities. In addition to its antioxidant activity, Orz is often associated with …

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein
kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine …

Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue,
skeletal muscle and liver, and these responses are significantly attenuated in insulin …

Stress response pathways are critical for cellular homeostasis, promoting survival through
adaptive changes in gene expression and metabolism. They play key roles in numerous …

The anesthetic-surgical stress response consists of metabolic, neuroendocrine,
hemodynamic, immunological, and behavioral adaptations through chemical mediators …

Objective The very low-density lipoprotein receptor (VLDLR) plays an important role in the
development of hepatic steatosis. In this study, we investigated the role of Peroxisome …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive decline.
Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and …