In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

Genetically modified animals are vital for gaining a proper understanding of disease
mechanisms. Mice have long been the mainstay of basic research into a wide variety of …

Background. A novel translational pharmacology investigation was conducted by combining
an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical …

Latent reservoirs of HIV-1-infected cells are refractory to antiretroviral therapies (ART) and
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …

The failure rate for the translation of drugs from animal testing to human treatments remains
at over 92%, where it has been for the past few decades. The majority of these failures are …

Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env)
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …

Different mechanisms mediate the toxicity of RNA. Genomic retroviral mRNA hijacks infected
host cell factors to enable virus replication. The viral genomic RNA of the human …

Numerous studies are exploring the use of cell adoptive therapies to treat hematological
malignancies as well as solid tumors. However, there are numerous factors that dampen the …

Despite the existence of a variety of contraceptive products for women, as well as decades
of research into the prevention and treatment of human immunodeficiency virus (HIV), there …

Current antiretroviral therapies have improved the duration and quality of life of people living
with HIV-1. However, viral reservoirs impede complete eradication of the virus. Although …