[HTML][HTML] Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

[HTML][HTML] Human cytomegalovirus and autoimmune diseases: where are we?

F Gugliesi, S Pasquero, G Griffante, S Scutera… - Viruses, 2021 - mdpi.com
Human cytomegalovirus (HCMV) is a ubiquitous double-stranded DNA virus belonging to
the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes …

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

CA Fielding, P Sabberwal, JC Williamson… - Elife, 2022 - elifesciences.org
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell
to evade immunity, and the ability of the immune response to overcome this evasion …

[HTML][HTML] ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission

EC Semmes, IG Miller, N Rodgers, CT Phan, JH Hurst… - JCI insight, 2023 - ncbi.nlm.nih.gov
Human cytomegalovirus (HCMV) is the most common vertically transmitted infection
worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) …

[HTML][HTML] Immune landscape of CMV infection in cancer patients: from “canonical” diseases toward virus-elicited oncomodulation

R El Baba, G Herbein - Frontiers in immunology, 2021 - frontiersin.org
Human Cytomegalovirus (HCMV) is an immensely pervasive herpesvirus, persistently
infecting high percentages of the world population. Despite the apparent robust host …

[PDF][PDF] Advances in the treatment of cytomegalovirus

BA Krishna, MR Wills, JH Sinclair - British Medical Bulletin, 2019 - academic.oup.com
Background Human cytomegalovirus (HCMV) is a threat to immunologically weak patients.
HCMV cannot yet be eliminated with a vaccine, despite recent advances. Sources of data …

[HTML][HTML] Tumors and cytomegalovirus: An intimate interplay

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that alternates lytic and latent infection,
infecting between 40 and 95% of the population worldwide, usually without symptoms …

HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation

VM Vlachava, S Seirafian, CA Fielding… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (HCMV) is a paradigm of pathogen immune evasion and sustains
lifelong persistent infection in the face of exceptionally powerful host immune responses …

[HTML][HTML] HCMV latency: what regulates the regulators?

E Elder, J Sinclair - Medical microbiology and immunology, 2019 - Springer
Human cytomegalovirus (HCMV) latency and reactivation is regulated by the chromatin
structure at the major immediate early promoter (MIEP) within myeloid cells. Both cellular …

[HTML][HTML] Battle between host immune cellular responses and HCMV immune evasion

T Manandhar, GGT Hò, WC Pump, R Blasczyk… - International journal of …, 2019 - mdpi.com
Human cytomegalovirus (HCMV) is ubiquitously prevalent. HCMV infection is typically
asymptomatic and controlled by the immune system in healthy individuals, yet HCMV can be …