Synthesis and transformations of nitrones for organic synthesis

SI Murahashi, Y Imada - Chemical reviews, 2019 - ACS Publications
Nitrones are important compounds and are highly useful in many aspects. The first part
describes the methods for synthesis of nitrones, which are useful and environmentally …

Bioorthogonal reactions utilizing nitrones as versatile dipoles in cycloaddition reactions

DA Bilodeau, KD Margison, M Serhan… - Chemical …, 2021 - ACS Publications
Bioorthogonal chemical reactions have emerged as convenient and rapid methods for
incorporating unnatural functionality into living systems. Different prototype reactions have …

Regio‐and Enantioselective (3+ 3) Cycloaddition of Nitrones with 2‐Indolylmethanols Enabled by Cooperative Organocatalysis

TZ Li, SJ Liu, YW Sun, S Deng, W Tan… - Angewandte Chemie …, 2021 - Wiley Online Library
Abstract The regio‐and enantioselective (3+ 3) cycloaddition of nitrones with 2‐
indolylmethanols was accomplished by the cooperative catalysis of hexafluoroisopropanol …

Visible light-promoted amide bond formation via one-pot nitrone in situ formation/rearrangement cascade

BG Cai, SS Luo, L Li, L Li, J Xuan, WJ Xiao - CCS Chemistry, 2021 - chinesechemsoc.org
A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-
promoted nitrone formation/rearrangement cascade was developed. This method utilized …

Stereoselective Photoredox Catalyzed (3+ 3) Dipolar Cycloaddition of Nitrone with Aryl Cyclopropane

Y Xu, HX Gao, C Pan, Y Shi, C Zhang… - Angewandte …, 2023 - Wiley Online Library
By resorting to the principle of remote activation, we herein demonstrate the first photoredox
catalyzed (3+ 3) dipolar cycloaddition of nitrones with aryl cyclopropanes. Key to the fidelity …

Nitrone Directing Groups in Rhodium (III)‐Catalyzed C− H Activation of Arenes: 1, 3‐Dipoles versus Traceless Directing Groups

F Xie, S Yu, Z Qi, X Li - Angewandte Chemie International …, 2016 - Wiley Online Library
Functionalizable directing groups (DGs) are highly desirable in C− H activation chemistry.
The nitrone DGs are explored in rhodium (III)‐catalyzed C− H activation of arenes and …

Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions

MR Becker, AD Richardson, CS Schindler - Nature Communications, 2019 - nature.com
Azetidines are four-membered nitrogen-containing heterocycles that hold great promise in
current medicinal chemistry due to their desirable pharmacokinetic effects. However, a lack …

Advances in asymmetric amino acid synthesis enabled by radical chemistry

VA Larionov, NV Stoletova… - Advanced Synthesis & …, 2020 - Wiley Online Library
Chiral amino acids (AAs), being the main “building” blocks of the living organisms, are also
an important class of organic compounds which broadly applied in synthetic chemistry …

Enantioselective synthesis of cyclic nitrones by chemoselective intramolecular allylic alkylation of oximes

T Sandmeier, EM Carreira - Angewandte Chemie International …, 2021 - Wiley Online Library
The enantio‐and chemoselective iridium‐catalyzed N‐allylation of oximes is described for
the first time. Intramolecular kinetic resolution provides access to cyclic nitrones and …

Asymmetric nitrone synthesis via ligand-enabled copper-catalyzed cope-type hydroamination of cyclopropene with oxime

Z Li, J Zhao, B Sun, T Zhou, M Liu, S Liu… - Journal of the …, 2017 - ACS Publications
We report realization of the first enantioselective Cope-type hydroamination of oximes for
asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene …