ADHESION IS REQUIRED for cell growth, differentiation, survival, and function. Nowhere is
this more evident than in the response to tissue injury, where vascular damage triggers …

Recent in vivo studies have highlighted the dynamic and complex nature of platelet
thrombus growth and the requirement for multiple adhesive receptor–ligand interactions in …

ADP is an important platelet agonist causing shape change and aggregation required for
physiological hemostasis. We recently demonstrated the existence of two distinct G protein …

ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential
targets for antithrombotic drugs. Two G-protein coupled P2 receptors contribute to platelet …

Increased platelet adhesion or aggregation are key events in the pathogenesis of
cardiovascular diseases. Exact determination of the platelet activation state is essential to …

Thrombin activates platelets in an ordered sequence of events that includes shape change,
increase in cytoplasmic Ca2+, activation of the αIIbβ3 integrin, granule secretion …

Cell adhesion, which plays a major role in the response of tissues to injury, involves a wide
variety of cells, adhesion receptors, and ligands. Prominent among the cells responding to …

It has become increasingly appreciated that receptors coupled to Gα i family members can
stimulate platelet aggregation, but the mechanism for this has remained unclear. One …

Inherited platelet-based bleeding disorders include abnormalities of platelet number and
function, and are generally classified based on the abnormal functions or responses …

Thromboxane A 2 (TXA 2)-mediated platelet secretion and aggregation are important in
thrombosis. Here, we present a novel finding that the stable TXA 2 analogue, U46619 …