Background Age is one of the strongest predictors of cancer, chronic disease, and mortality,
but biological responses to aging differ among people. Epigenetic DNA modifications have …

The association between aging and cancer is complex. Recent studies have developed
measures of biological aging based on DNA methylation and called them “age …

All tissues of the organism are affected by aging. This process is associated with epigenetic
modifications such as methylation changes at specific cytosine residues in the DNA (CpG …

Aging is a multifactorial process characterized by the progressive loss of physiological
functions, leading to an increased vulnerability to age‐associated diseases and finally to …

Compared with younger people, older people are much more variable in their organ
function, and these large individual differences contribute to the complexity of geriatric …

Next-generation sequencing (NGS) technology, with its high-throughput capacity and low
cost, has developed rapidly in recent years and become an important analytical tool for …

Organisms can change their physiological/behavioural traits to adapt and survive in
changed environments. However, whether these acquired traits can be inherited across …

DNA methylation-based biomarkers of aging are highly correlated with actual age.
Departures of methylation-estimated age from actual age can be used to define epigenetic …

Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …

Biological aging is the main driver of age‐associated chronic diseases. In 2014, the United
States National Institute of Aging (NIA) sponsored a meeting between several investigators …