[HTML][HTML] Drug addiction and treatment: An epigenetic perspective

AS Koijam, KD Singh, BS Nameirakpam… - Biomedicine & …, 2024 - Elsevier
Drug addiction is a complex disease affected by numerous genetic and environmental
factors. Brain regions in reward pathway, neuronal adaptations, genetic and epigenetic …

Assessing Biological Age: The Potential of ECG Evaluation Using Artificial Intelligence: JACC Family Series

F Lopez-Jimenez, S Kapa, PA Friedman… - Clinical …, 2024 - jacc.org
Biological age may be a more valuable predictor of morbidity and mortality than a person's
chronological age. Mathematical models have been used for decades to predict biological …

[HTML][HTML] Anti-Aging Strategies to Prevent Diseases: Promoting Longevity and Optimal Health

M Farrokhi, F Taheri, M Farrokhi, A Moeini… - Kindle, 2024 - preferpub.org
Anti-aging strategies extend beyond cosmetic concerns, reaching into the realm of disease
prevention, promoting longevity, and optimizing overall health. The quest for a longer …

A Computational Approach for the Discovery of Novel DNA Methyltransferase Inhibitors

E Kritsi, P Christodoulou, T Tsiaka… - Current Issues in …, 2024 - mdpi.com
Nowadays, the explosion of knowledge in the field of epigenetics has revealed new
pathways toward the treatment of multifactorial diseases, rendering the key players of the …

Effect of resistance training plus enriched probiotic supplement on sestrin2, oxidative stress, and mitophagy markers in elderly male Wistar rats

M Mohabbat, H Arazi - Scientific Reports, 2024 - nature.com
This study aimed to determine the effects of resistance training combined with a probiotic
supplement enriched with vitamin D and leucine on sestrin2, oxidative stress, antioxidant …

3D-bioprinted anti-senescence organoid scaffolds repair cartilage defect and prevent joint degeneration via miR-23b/ELOVL5-mediated metabolic rewiring

Y Wang, Y You, H Chen, J Liu, Q Wu, K Dai… - Chemical Engineering …, 2024 - Elsevier
Introduction Osteoarthritis (OA) is the most prevalent degenerative disease worldwide and
commonly occurs among the elderly. At present, there is no effective treatment for OA. When …

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation

M Ibragimova, A Kussainova, A Aripova, R Bersimbaev… - Cells, 2024 - mdpi.com
This review discusses the relationship between cellular senescence and radiation exposure.
Given the wide range of ionizing radiation sources encountered by people in professional …

Underlying Mechanisms of the Protective Effects of Lifestyle Factors in the Prevention of Age-Related Diseases

N Alcaráz, P Salcedo-Tello, R González-Barrios… - Archives of Medical …, 2024 - Elsevier
The rise in life expectancy has significantly increased the occurrence of age-related chronic
diseases, leading to escalating expenses for both society and individuals. Among the main …

The evidence to date: implications of l-ascorbic acid in the pathophysiology of aging

A Sato, Y Kondo, A Ishigami - The Journal of Physiological Sciences, 2024 - Springer
L-Ascorbic acid, commonly known as vitamin C, has been used not only for disease
prevention and in complementary and alternative medicine, but also for anti-aging purposes …

Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

XW Liu, HW Xu, YY Yi, SB Zhang, SJ Chang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Age-related osteoporosis is characterized by a marked decrease in the number of
osteoblasts, which has been partly attributed to the senescence of cells of the osteoblastic …