Fibroblasts synthesize the extracellular matrix of connective tissue and play an essential role
in maintaining the structural integrity of most tissues. Researchers have long suspected that …

Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …

Fibroblasts are an essential cell population for human skin architecture and function. While
fibroblast heterogeneity is well established, this phenomenon has not been analyzed …

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth
muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the …

INTRODUCTION Fibroblasts produce extracellular matrix (ECM) molecules that regulate
tissue strength and resilience. Imbalanced ECM maintenance leads to tissue dysfunction …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment
of nonhealing cutaneous ulcers. However, such nonnative skin grafts fail to permanently …

Fibroblasts produce matrix, regulate inflammation, mediate reparative processes, and serve
as pluripotent mesenchymal cells. Analyzing digested normal human skin by single-cell …

The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

Wound healing requires a coordinated interplay among cells, growth factors, and
extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem …