Developmental biology-inspired strategies for tissue-building have extraordinary promise for
regenerative medicine, spurring interest in the relationship between cell biophysical …

Complex three‐dimensional in vitro organ‐like models, or organoids, offer a unique
biological tool with distinct advantages over two‐dimensional cell culture systems, which …

In vitro and in vivo models play integral roles in preclinical drug research, evaluation, and
precision medicine. In vitro models primarily involve research platforms based on cultured …

The present study investigated the effect of single as well as a mixture of nanoparticles (ZnO
and CuO NPs) on algae–bacteria consortia using the OECD 96-h toxicity test, one of the first …

Recent advances in induced pluripotent stem cells (iPSCs), genome editing technologies
and 3D organoid model systems highlight opportunities to develop new in vitro human …

Drug‐induced nephrotoxicity causes huge morbidity and mortality at massive financial cost.
The greatest burden of drug‐induced acute kidney injury falls on the proximal tubular cells …

The generation of kidney organoids from human pluripotent stem cells (hPSCs) has
represented a relevant scientific achievement in the organoid field. Importantly, hPSC …

Organoids derived from human stem cells are a promising approach for disease modeling,
regenerative medicine, and fundamental research. However, organoid variability and limited …

Kidneys are complex organs, and reproducing their function and physiology in a laboratory
setting remains difficult. During drug development, potential compounds may exhibit …

The human kidney, which consists of up to 2 million nephrons, is critical for blood filtration,
electrolyte balance, pH regulation, and fluid balance in the body. Animal experiments …