During kidney development, nephron epithelia arise de novo from fate-committed
mesenchymal progenitors through a mesenchymal-to-epithelial transition (MET) …

During embryonic development, the mesoderm undergoes patterning into diverse lineages
including axial, paraxial, and lateral plate mesoderm (LPM). Within the LPM, the so-called …

Background: Human testicular cells are greatly valuable to the research community as tools
for studying testicular physiology and the effects of environmental pollutants. Because adult …

In recent years, the successful construction of tissues derived from established iPSCs has
been disclosed, but it has been reported that the constructed tissues encounter problems of …

Nephrotic syndrome is classically categorized by the histopathology with examples
including focal segmental glomerulosclerosis (FSGS) and minimal change disease …

Kidney organoids differentiated from human pluripotent stem cells (hPSC) have advanced
the study of kidney diseases by providing an in vitro system that outperforms traditional …

Kidney organoids can be generated from induced pluripotent stem cells (iPSCs) through
various approaches. These organoids hold great promise for disease modeling, drug …

Kidney transplantation is at present the only definitive treatment for patients with end-stage
kidney disease that can improve the quality of life compared with dialysis. However, donor …

Engineering of embryonic strategies for tissue-building has extraordinary promise for
regenerative medicine. This has led to a resurgence in interest in the relationship between …

We describe an open source Human Commons Cell Atlas comprising 2.9 million cells
across 27 tissues that can be easily updated and that is structured to facilitate custom …