Unraveling the tumor microenvironment: insights into cancer metastasis and therapeutic strategies

M El-Tanani, SA Rabbani, R Babiker, I Rangraze… - Cancer Letters, 2024 - Elsevier
This comprehensive review delves into the pivotal role of the tumor microenvironment (TME)
in cancer metastasis and therapeutic response, offering fresh insights into the intricate …

[HTML][HTML] Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer

D van der Graaff, S Seghers, P Vanclooster, C Deben… - Cancers, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) remains a significant health burden globally, being the second
leading cause of cancer-related mortality. Despite significant therapeutic advancements …

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system

S Spisak, D Chen, P Likasitwatanakul, P Doan… - Nature …, 2024 - nature.com
Aberrant stem cell-like activity and impaired differentiation are central to the development of
colorectal cancer (CRC). To identify functional mediators of these key cellular programs, we …

The challenge of making the right choice: patient avatars in the era of cancer immunotherapies

C Kayser, A Brauer, S Susanne… - Frontiers in …, 2023 - frontiersin.org
Immunotherapies are a key therapeutic strategy to fight cancer. Diverse approaches are
used to activate tumor-directed immunity and to overcome tumor immune escape. The …

Organoid-Based Assessment of Metal–Organic Framework (MOF) Nanomedicines for Ex Vivo Cancer Therapy

D Li, R Zhang, Y Le, T Zhang, D Luo… - … Applied Materials & …, 2024 - ACS Publications
Nanomaterials have been extensively exploited in tumor treatment, leading to numerous
innovative strategies for cancer therapy. While nanomedicines present immense potential …

A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells

P Fonseca, W Cui, N Struyf, L Tong… - Journal of Experimental …, 2024 - Springer
Background Tumor cells have the ability to invade and form small clusters that protrude into
adjacent tissues, a phenomenon that is frequently observed at the periphery of a tumor as it …

Ultrasmall Carbon Nanodots as Theranostic Nanoheaters for Precision Breast Cancer Phototherapy: Establishing the Translational Potential in Tumor-in-a-Dish …

G Roscigno, A Affinito, C Quintavalle… - ACS Biomaterials …, 2024 - ACS Publications
This study investigates the remarkable attributes of sulfur-doped carbon nanodots (CDs)
synthesized in high yield and a narrow size distribution (4.8 nm). These CDs exhibit notable …

Extracellular Vesicles in Breast Cancer: From Intercellular Communication to Therapeutic Opportunities

B Muttiah, SL Ng, Y Lokanathan, MH Ng, JX Law - Pharmaceutics, 2024 - mdpi.com
Breast cancer, a multifaceted and heterogeneous disease, poses significant challenges in
terms of understanding its intricate resistance mechanisms and devising effective …

Organ mimicking technologies and their applications in drug discovery

X Zhang, Y Luo, Q Wang - Frontiers in Bioengineering and …, 2023 - frontiersin.org
The drug discovery industry has gradually recognized the importance of biomimetic
evaluation methods in nonclinical tests, particularly with the recent introduction of the FDA …

Drug repurposing for cancer.

J Banerjee, AK Tiwari, S Banerjee - Progress in Molecular Biology …, 2024 - europepmc.org
In the dynamic landscape of cancer therapeutics, the innovative strategy of drug repurposing
emerges as a transformative paradigm, heralding a new era in the fight against …