The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors

G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …

[HTML][HTML] From cell spheroids to vascularized cancer organoids: Microfluidic tumor-on-a-chip models for preclinical drug evaluations

Y Wu, Y Zhou, X Qin, Y Liu - Biomicrofluidics, 2021 - pubs.aip.org
Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …

All-aerosol-sprayed high-performance transparent triboelectric nanogenerator with embedded charge-storage layer for self-powered invisible security IoT system and …

BG Kim, JY Song, M Kim, ZH Lin, D Choi, SM Park - Nano Energy, 2022 - Elsevier
Practical utilization of the triboelectric nanogenerators (TENGs), which have unique
advantageous aspects of a simple operation mechanism, material selection diversity, and …

Flipped well-plate hanging-drop technique for growing three-dimensional tumors

Y Jeong, A Tin, J Irudayaraj - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Three-dimensional (3D) tumor culture techniques are gaining popularity as in vitro models of
tumoral tissue analogues. Despite the widespread interest, need, and present-day effort …

Spontaneous formation of 3D breast cancer tissues on electrospun chitosan/poly (ethylene oxide) nanofibrous scaffolds

AMI Rabie, ASM Ali, MA Al-Zeer, A Barhoum… - ACS …, 2022 - ACS Publications
Three-dimensional (3D) tissue culture has attracted a great deal of attention as a result of
the need to replace the conventional two-dimensional cell cultures with more meaningful …

Uniform-thickness electrospun nanofiber mat production system based on real-time thickness measurement

HI Ryu, MS Koo, S Kim, S Kim, YA Park, SM Park - Scientific reports, 2020 - nature.com
Electrospinning is a simple versatile process used to produce nanofibers and collect them
as a nanofiber mat. However, due to bending instability, electrospinning often produces a …

Intersection of nanomaterials and organoids technology in biomedicine

C Shen, Z Zhang, X Li, Y Huang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the
conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types …

Conformal fabrication of an electrospun nanofiber mat on a 3D ear cartilage-shaped hydrogel collector based on hydrogel-assisted electrospinning

JY Song, HI Ryu, JM Lee, SH Bae, JW Lee… - Nanoscale Research …, 2021 - Springer
Electrospinning is a common and versatile process to produce nanofibers and deposit them
on a collector as a two-dimensional nanofiber mat or a three-dimensional (3D) macroscopic …

Gold nanostructure-integrated conductive microwell arrays for uniform cancer spheroid formation and electrochemical drug screening

FN Ju, CH Kim, KH Lee, CD Kim, J Lim, T Lee… - Biosensors and …, 2023 - Elsevier
Cancer spheroids, which mimic distinct cell-to-cell and cell-extracellular matrix interactions
of solid tumors in vitro, have emerged as a promising tumor model for drug screening …

Optimizing an injectable composite oxygen-generating system for relieving tissue hypoxia

TE Hsieh, SJ Lin, LC Chen, CC Chen, PL Lai… - … in Bioengineering and …, 2020 - frontiersin.org
Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive
cell death and delayed osteoblast differentiation, ultimately impairing new bone formation …