Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

Cancer heterogeneity has posed a great challenge to traditional cancer treatment, with the
reappearance of cancer heterogeneity of inter and intra patients being especially critical …

Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

Introduction: Most advanced colorectal cancers are aggressive, and there is a lack of
effective methods for selecting appropriate anticancer regimens. Patient-derived organoids …

Organoids are a new type of 3D model for tumor research, which makes up for the
shortcomings of cell lines and xenograft models, and promotes the development of …

While chemotherapy alone or in combination with radiotherapy and surgery are important
modalities in the treatment of colorectal cancer, their widespread use is not paired with an …

Cancer remains a severe public health burden worldwide. One of the challenges hampering
effective cancer therapy is that the existing cancer models hardly recapitulate the tumor …

Methods accurately predicting the responses of colorectal cancer (CRC) and colorectal
cancer liver metastasis (CRLM) to personalized chemotherapy remain limited due to tumor …