Heart disease and stroke statistics—2018 update: a report from the American Heart Association

EJ Benjamin, SS Virani, CW Callaway… - Circulation, 2018 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Chronic kidney disease

P Romagnani, G Remuzzi, R Glassock… - Nature reviews Disease …, 2017 - nature.com
Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural
abnormalities or impaired excretory renal function suggestive of a loss of functional …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

A Levin, M Tonelli, J Bonventre, J Coresh, JA Donner… - The Lancet, 2017 - thelancet.com
The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Mechanisms of renal fibrosis

BD Humphreys - Annual review of physiology, 2018 - annualreviews.org
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Uromodulin: from physiology to rare and complex kidney disorders

O Devuyst, E Olinger, L Rampoldi - Nature Reviews Nephrology, 2017 - nature.com
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

JN Hellwege, DR Velez Edwards, A Giri, C Qiu… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR),
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …

Promises of big data and artificial intelligence in nephrology and transplantation

C Thongprayoon, W Kaewput, K Kovvuru… - Journal of clinical …, 2020 - mdpi.com
Kidney diseases form part of the major health burdens experienced all over the world.
Kidney diseases are linked to high economic burden, deaths, and morbidity rates. The great …

What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis

M Gonzalez-Quiroz, N Pearce, B Caplin… - Clinical kidney …, 2018 - academic.oup.com
Background The aim of this systematic review is to examine the epidemiological knowledge
and gaps in understanding of the potential causes of chronic kidney disease of …

[HTML][HTML] Big science and big data in nephrology

J Saez-Rodriguez, MM Rinschen, J Floege… - Kidney international, 2019 - Elsevier
There have been tremendous advances during the last decade in methods for large-scale,
high-throughput data generation and in novel computational approaches to analyze these …