Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

The 5-year overall survival rate remains approximately 50% for head and neck (H&N)
cancer patients, even though new cancer drugs have been approved for clinical use since …

Abstract 3D cell culture is becoming increasingly important for mimicking physiological
tissue structures in areas such as drug discovery and personalized medicine. To enable …

Colorectal cancer is one of the most important malignancies worldwide, with high incidence
and mortality rates. Several studies have been conducted using two-dimensional cultured …

A lack of practical resources in Japan has limited preclinical discovery and testing of
therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which …

Human-relevant systems that mimic the 3D tumor microenvironment (TME), particularly the
complex mechanisms of immuno-modulation in the tumor stroma, in a reproducible and …

Simple Summary This review article delves into the expanding role of 3D culture models in
advancing breast cancer biology comprehension and enhancing drug response predictions …

3D bioprinting is an additive manufacturing method, formulated with cells printed in bioinks
of basic matrix such as hydrogels. Bioinks are relevant to precision medicine mainly due to …

Patient-derived xenograft (PDX) models faithfully preserve the histological and genetic
characteristics of the primary tumor and maintain its heterogeneity. Pharmacodynamic …

Patient-derived tumor organoids (PDOs) are expected to be a preclinical cancer model with
better reproducibility of disease than traditional cell culture models. PDOs have been …