Expanding the frontiers of guardian antioxidant selenoproteins in cardiovascular pathophysiology

T Angelone, C Rocca, V Lionetti, C Penna… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Physiological levels of reactive oxygen and nitrogen species (ROS/RNS)
function as fundamental messengers for many cellular and developmental processes in the …

Obesity and cancer rehabilitation for functional recovery and quality of life in breast cancer survivors: a comprehensive review

L Lippi, A de Sire, A Folli, A Turco, S Moalli… - Cancers, 2024 - mdpi.com
Simple Summary Obesity is a global health challenge closely linked to breast cancer (BC).
Recognizing this intricate relationship, our research explores the multifaceted connections …

Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction

MW Rudokas, M McKay, Z Toksoy, JN Eisen… - Cardiovascular …, 2024 - Springer
Mitochondria play a central role in cellular energy metabolism, and their dysfunction is
increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac …

Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest

S Piel, MJ McManus, KN Heye, F Beaulieu… - Scientific Reports, 2024 - nature.com
Neurological and cardiac injuries are significant contributors to morbidity and mortality
following pediatric in-hospital cardiac arrest (IHCA). Preservation of mitochondrial function …

Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects

Z Chen, Z Li, R Xu, Y Xie, D Li… - Journal of Medicinal …, 2024 - ACS Publications
Cardiovascular diseases (CVDs) persist as the predominant cause of mortality, urging the
exploration of innovative pharmaceuticals. Mitochondrial dysfunction stands as a pivotal …

Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma

H Zhang, H Wang, Y Hu, Y Gao, J Chen, Y Meng, Y Qiu… - Cancer Letters, 2024 - Elsevier
Multiple myeloma (MM) is a hematological malignancy that remains incurable, primarily due
to the high likelihood of relapse or development of resistance to current treatments. To …

Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity

R Torcasio, ME Gallo Cantafio, C Veneziano… - Journal of Translational …, 2024 - Springer
Background Mitochondrial alterations, often dependent on unbalanced mitochondrial
dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM) …

The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure

A De Bartolo, T Pasqua, N Romeo, V Rago… - Journal of Translational …, 2024 - Springer
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The
oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat …

Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity?

P Kleinbongard, I Andreadou - Current Heart Failure Reports, 2024 - Springer
Abstract Purpose of Review To provide an overview of (a) protective effects on mitochondria
induced by remote ischemic conditioning (RIC) and (b) mitochondrial damage caused by …

The Cellular Stress and Cutaneous Manifestations in Renal Cell Carcinomas—A Narrative Review

CD Ene, I Nicolae, M Tampa, SR Georgescu… - Journal of Clinical …, 2024 - mdpi.com
The carcinomas originating from the renal cortex are the most aggressive renal
malignancies, with a high tendency for metastasis. Understanding the incidence of …