Associations between mitochondrial copy number, exercise capacity, physiologic cost of walking, and cardiac strain in young adult survivors of childhood cancer

AM Berkman, CG Goodenough, P Durakiewicz… - Journal of Cancer …, 2024 - Springer
Purpose Childhood cancer survivors are at risk for cardiac dysfunction and impaired
physical performance, though underlying cellular mechanisms are not well studied. In this …

Building the case for mitochondrial transplantation as an anti-aging cardiovascular therapy

CA Headley, PS Tsao - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Mitochondrial dysfunction is a common denominator in both biological aging and
cardiovascular disease (CVD) pathology. Understanding the protagonist role of …

Cardioprotective potential of compound 3K, a selective PKM2 inhibitor in isoproterenol-induced acute myocardial infarction: A mechanistic study

M Rihan, SS Sharma - Toxicology and Applied Pharmacology, 2024 - Elsevier
Myocardial infarction (MI) or heart attack arises from acute or chronic prolonged ischemic
conditions in the myocardium. Although several risk factors are associated with MI …

[HTML][HTML] Resveratrol combats chronic diseases through enhancing mitochondrial quality

W Tao, H Zhang, X Jiang, N Chen - Food Science and Human Wellness, 2024 - Elsevier
Resveratrol (RSV), as a functional food component extracted from natural plants, has been
widely studied and recognized in preventing and treating various diseases, with major …

Characterizing early cardiac metabolic programming via 30% maternal nutrient reduction during fetal development in a non-human primate model

SP Pereira, MS Diniz, LC Tavares… - International Journal of …, 2023 - mdpi.com
Intra-uterine growth restriction (IUGR) is a common cause of fetal/neonatal morbidity and
mortality and is associated with increased offspring predisposition for cardiovascular …

PM2.5 Exposure-Linked Mitochondrial Dysfunction Negates SB216763-Mediated Cardio-Protection against Myocardial Ischemia–Reperfusion Injury

B Sivakumar, A Nadeem, MA Dar, GA Kurian - Life, 2023 - mdpi.com
GSK3β is a promising target for treating various disease conditions, including myocardial
ischemia–reperfusion injury (IR). This study investigated the potential of GSK3β as a novel …

Atmospheric fine particulate matter (PM2. 5) induces pulmonary fibrosis by regulating different cell fates via autophagy

B Liu, Y Han, Y Ye, X Wei, G Li, W Jiang - Science of The Total Environment, 2024 - Elsevier
The presence of respiratory diseases demonstrates a positive correlation with atmospheric
fine particulate matter (PM 2.5) exposure. The respiratory system is the main target organ …

Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials

CA Stamerra, P Di Giosia, P Giorgini… - Current Atherosclerosis …, 2024 - Springer
Purpose of review Heart failure (HF) is one of the main causes of cardiovascular mortality in
the western world. Despite great advances in treatment, recurrence and mortality rates …

Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis

W Liu, X Zhao, X Wu - Journal of Orthopaedic Surgery and Research, 2023 - Springer
Background Increasing evidence suggests that mitophagy is responsible for the
pathogenesis of intervertebral disk (IVD) degeneration. Previous studies have shown that …

[HTML][HTML] Mitofilin in Cardiovascular Diseases: Insights into the Pathogenesis and Potential Pharmacological Interventions

AI Chaurembo, N Xing, F Chanda, Y Li, H Zhang… - Pharmacological …, 2024 - Elsevier
The impact of mitochondrial dysfunction on the pathogenesis of cardiovascular disease is
increasing. However, the precise underlying mechanism remains unclear. Mitochondria …