Fibrinogen and fibrin play an important role in blood clotting, fibrinolysis, cellular and matrix
interactions, inflammation, wound healing, angiogenesis, and neoplasia. The contribution of …

From the initial description of platelets in 1882, their propensity to aggregate and to
contribute to thrombosis was apparent. Indeed, excessive platelet aggregation is associated …

Thrombin plays a central role in normal and abnormal hemostatic processes. It is assumed
that α-thrombin activates platelets by hydrolyzing the protease-activated receptor (PAR)-1 …

Integrin α v β 3 recognizes fibrinogen γ and α E chain C-terminal domains (γC and α EC) but
does not require the γC dodecapeptide sequence HHLGGAKQAGDV 400–411 for binding to …

Integrin αvβ3, a widely distributed fibrinogen receptor, recognizes the RGD572-574 motif in
the α chain of human fibrinogen. However, this motif is not conserved in other species, nor is …

After achievement of adequate anticoagulation, the natural history of acute pulmonary
emboli ranges from near total resolution of vascular perfusion to long-term persistence of …

This study employs tissue-engineering technologies to evaluate neutrophil interactions with
extracellular matrix (ECM)-mimetic peptides. We have used a polyethylene glycol (PEG) …

Fibrinogen is a plasma protein that interacts with integrin αIIbβ3 to mediate a variety of
platelet responses including adhesion, aggregation, and clot retraction. Three sites on …

CTEPH may be due to a complex interaction between thrombotic/thrombolytic processes
and angiogenic cellular remodeling of organized thrombi. The factors involved may, in fact …

The interactions of platelets with fibrinogen mediate a variety of responses including
adhesion, platelet aggregation, and fibrin clot retraction. Whereas it was assumed that …