Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

Metastasis to bone frequently occurs in majority of patients with advanced breast cancer and
prostate cancer, leading to devastating skeletal-related events and substantially reducing …

Platelet adhesion, activation and aggregation on the exposed subendothelial extracellular
matrix (ECM) are essential for haemostasis, but may also lead to occlusion of diseased …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …

Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The
structure–function relationship of integrins remains incompletely understood, despite the …

Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous
human cancers. OPN functions in cell adhesion, chemotaxis, macrophage-directed …

Many similarities exist in the cellular responses elicited by VEGF and governed by integrins.
Here, we identify a basis for these interrelationships: VEGF activates integrins. VEGF …

Osteopontin (Opn) is a secreted adhesive, glycosylated phosphoprotein that contains the
arginine‐glycine‐aspartic acid (RGD) cell‐binding sequence that is found in many …