An emerging concept is that disulfide bonds can act as a dynamic scaffold to present mature
proteins in different conformational and functional states on the cell surface. Two examples …

Objective—Platelet activation mediates multiple cellular responses, including secretion of
chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs). We …

The discovery of the genetic code was one of the milestone events in biology: a conserved,
universal code defining the primary amino acid sequences of all proteins of all organisms …

The inhibition of blood platelet aggregation and secretion was studied using covalent thiol
reagents, maleimides, or mercuribenzoates, or using inhibitors of protein disulfide …

Sulfhydryl and disulfide metabolism in platelet function has recently reemerged as a focus of
platelet research. In this study we tested the effect of redox buffer on platelet aggregation …

Protein disulfide isomerase (PDI), an oxidoreductase, possesses two vicinal cysteines in the-
Cys-Gly-His-Cys-motif that either form a disulfide bridge (S–S) or exist in a sulfhydryl form …

Disulfide bonds formed in newly synthesized proteins in the endoplasmic reticulum of cells
are important for protein structure and stability. Recent research, however, emphasizes a …

Integrin αIIbβ3 mediated bidirectional signaling plays a critical role in thrombosis and
haemostasis. Signaling mediated by the β3 subunit has been extensively studied, but αIIb …

Decreased expression of functional IIbβ3 complexes on the platelet surface produces
Glanzmann thrombasthenia. We have identified mutations of IIbP145 in 3 ethnically distinct …

The platelet integrin receptor αIIbβ3 plays a critical role in thrombosis and haemostasis by
mediating interactions between platelets and several ligands but primarily fibrinogen. It has …