Highlights•Mitochondria are involved in various physiochemical and biochemical
processes.•Owing to their crucial role in cellular metabolism, mitochondria are favored …

Limited by spatial and temporal resolution, traditional optical microscopy cannot image the
delicate ultra-structure organelles and sub-organelles. The emergence of super-resolution …

The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated
fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes …

Combining probes with advanced imaging techniques has enabled single-organelle
localization-based super-resolution imaging, revolutionizing our ability to investigate …

Mitochondria are dynamic organelles that undergo fusion and fission events, in which the
mitochondrial membrane and DNA (mtDNA) play critical roles. The spatiotemporal …

Enhanced targeting approaches will support the treatment of diseases associated with
dysfunctional mitochondria, which play critical roles in energy generation and cell survival …

Structured illumination microscopy (SIM) is a super-resolution technology for imaging living
cells and has been used for studying the dynamics of lysosomes and mitochondria …

Small molecule drugs play a pivotal role in the arsenal of anticancer pharmacological
agents. Nonetheless, their small size poses a challenge when directly visualizing their …

Cytosolic delivery of proteins and peptides provides opportunities for effective disease
treatment, as they can specifically modulate intracellular processes. However, most of …

Unlike chemosynthetic drugs designed for specific molecular and disease targets, active
small-molecule natural products typically have a wide range of bioactivities and multiple …