Lung macrophages mature after birth, placing newborn infants, particularly those born
preterm, within a unique window of susceptibility to disease. We hypothesized that in …

Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in
inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the …

Introduction: Intra-amniotic inflammation (IAI) or chorioamnionitis is a common complication
of pregnancy producing significant maternal morbidity/mortality, premature birth and …

The prenatal and perinatal environments can have profound effects on the development of
chronic inflammatory diseases. However, mechanistic insight into how the early-life …

The purpose of this study is to test the hypothesis that higher consumption of human milk
(HM) in preterm infants with birth weight (BW)< 1000 g is associated with improved lung …

Mechanical ventilation is a risk factor for the development of bronchopulmonary dysplasia in
premature infants. Fifteen minutes of high tidal volume (Vt) ventilation induces inflammatory …

The proinflammatory stimulus of chorioamnionitis is commonly associated with preterm
delivery. Women at risk of preterm delivery receive antenatal glucocorticoids to functionally …

Interleukin‐1β (IL‐1β) production is impaired in cord blood monocytes. However, the
mechanism underlying this developmental attenuation remains unclear. Here, we analyzed …

Very low birth weight preterm newborns are susceptible to the development of debilitating
inflammatory diseases, many of which are associated with chorioamnionitis. To define the …

The chorioamnionitis associated with preterm delivery is often polymicrobial with
ureaplasma being the most common isolate. To evaluate interactions between the different …