Pre-term infants are at greater risk for systemic infection due to an underdeveloped immune
system. Airway infection results in immune up-regulation of early pro-inflammatory cytokines …

Background Neonatal encephalopathy (NE) contributes substantially to child mortality and
disability globally. We compared cytokine profiles in term Ugandan neonates with and …

Bronchopulmonary dysplasia (BPD), associated with chorioamnionitis, results from the
simultaneous effects of disrupted lung development, lung injury, and repair superimposed …

Group B Streptococcus (GBS) is one of the most common bacteria isolated in human
chorioamnionitis. Placental infection due to GBS is a major risk factor for fetal organ injuries …

Background Initiation of ventilation using high tidal volumes in preterm lambs causes lung
injury and inflammation. Antenatal corticosteroids mature the lungs of preterm infants and …

We tested the hypothesis that interleukin 1 (IL-1) mediates intra-amniotic lipopolysaccharide
(LPS)-induced chorioamnionitis in preterm fetal sheep. Time-mated Merino ewes with …

Background The efficacy of antenatal steroids for fetal lung maturation in the periviable
period is not fully understood. Objective We sought to determine the lung maturational …

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Many extremely low birth weight (LBW) neonates now survive with intensive care. Their
survival depends on fetal and neonatal adaptations of multiple organ systems, which …

To understand the changes in the structural integrity of fetal membranes during intrauterine
inflammation, we evaluated the time course of expression and localization of damage …