Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …
A Letafati, S Najafi, M Mottahedi, M Karimzadeh… - Cellular & Molecular …, 2022 - Springer
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In …
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir,, primarily in resting memory CD4+ T cells,. This reservoir presents a …
CA Lozupone, M Li, TB Campbell, SC Flores… - Cell host & …, 2013 - cell.com
Understanding gut microbiota alterations associated with HIV infection and factors that drive these alterations may help explain gut-linked diseases prevalent with HIV. 16S rRNA …
J Hemelaar - Trends in molecular medicine, 2012 - cell.com
This review examines the enormous progress that has been made in the past decade in understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity …
International HIV Controllers Study - Science, 2010 - science.org
Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations …
A Halper-Stromberg, CL Lu, F Klein, JA Horwitz… - Cell, 2014 - cell.com
Latent reservoirs of HIV-1-infected cells are refractory to antiretroviral therapies (ART) and remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …
The development of an effective vaccine has been hindered by the enormous diversity of human immunodeficiency virus‐1 (HIV‐1) and its ability to escape a myriad of host immune …
TJ Henrich, H Hatano, O Bacon, LE Hogan… - PLoS …, 2017 - journals.plos.org
Background It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …