[HTML][HTML] Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68
Y Wang, SA Tibbetts, LT Krug - Annual review of virology, 2021 - annualreviews.org
Gammaherpesviruses are an important class of oncogenic pathogens that are exquisitely
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …
Structural organization, evolution, and distribution of viral pyrimidine dimer-DNA glycosylases
AN Karmanova, NA Nikulin, AA Zimin - Biophysical Reviews, 2022 - Springer
DNA glycosylases are DNA repair enzymes capable of removing damaged nitrogenous
bases, including those formed as a result of UV irradiation with sunlight (approximately 300 …
bases, including those formed as a result of UV irradiation with sunlight (approximately 300 …
Divergent structures of mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity
Uracil DNA glycosylase (UNG) removes mutagenic uracil base from DNA to initiate base
excision repair (BER). The result is an abasic site (AP site) that is further processed by the …
excision repair (BER). The result is an abasic site (AP site) that is further processed by the …
[HTML][HTML] 5-Ethynyl-2′-deoxycytidine and 5-ethynyl-2′-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses
S Manska, R Octaviano, CC Rossetto - Journal of Biological Chemistry, 2020 - ASBMB
Nucleoside analogues are a valuable experimental tool. Incorporation of these molecules
into newly synthesized DNA (ie pulse-labeling) is used to monitor cell proliferation or to …
into newly synthesized DNA (ie pulse-labeling) is used to monitor cell proliferation or to …
Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire
MA Zelazowska, Q Dong, JB Plummer… - Life science …, 2020 - life-science-alliance.org
The gammaherpesviruses (γHVs), human Kaposi sarcoma-associated herpesvirus (KSHV),
EBV, and murine γHV68 are prevalent infections associated with lymphocyte pathologies …
EBV, and murine γHV68 are prevalent infections associated with lymphocyte pathologies …
[HTML][HTML] The essential co-option of uracil-DNA glycosylases by herpesviruses invites novel antiviral design
R Savva - Microorganisms, 2020 - mdpi.com
Vast evolutionary distances separate the known herpesviruses, adapted to colonise
specialised cells in predominantly vertebrate hosts. Nevertheless, the distinct herpesvirus …
specialised cells in predominantly vertebrate hosts. Nevertheless, the distinct herpesvirus …
Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins
and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil …
and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil …
[HTML][HTML] A recombinant antibody for tracking murine gammaherpesvirus 68 uracil DNA glycosylase expression
Antibodies are powerful tools to detect expressed proteins. However off-target recognition
can confound their use. Therefore, careful characterization is needed to validate specificity …
can confound their use. Therefore, careful characterization is needed to validate specificity …
[HTML][HTML] Correlated Target Search by Vaccinia Virus Uracil–DNA Glycosylase, a DNA Repair Enzyme and a Processivity Factor of Viral Replication Machinery
The protein encoded by the vaccinia virus D4R gene has base excision repair uracil–DNA N-
glycosylase (vvUNG) activity and also acts as a processivity factor in the viral replication …
glycosylase (vvUNG) activity and also acts as a processivity factor in the viral replication …