New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

EM McCabe, TP Rasmussen - Seminars in cancer biology, 2021 - Elsevier
Epithelial to mesenchymal transition (EMT) is a cellular process in which cells composing
epithelial tissue lose requirements for physical contact with neighboring cells and acquire …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

[HTML][HTML] Epithelial-mesenchymal transitions in development and disease

JP Thiery, H Acloque, RYJ Huang, MA Nieto - cell, 2009 - cell.com
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …

TGF-β-induced epithelial to mesenchymal transition

J Xu, S Lamouille, R Derynck - Cell research, 2009 - nature.com
During development and in the context of different morphogenetic events, epithelial cells
undergo a process called epithelial to mesenchymal transition or transdifferentiation (EMT) …

Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression

DS Micalizzi, SM Farabaugh, HL Ford - Journal of mammary gland biology …, 2010 - Springer
From the earliest stages of embryonic development, cells of epithelial and mesenchymal
origin contribute to the structure and function of developing organs. However, these …

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

J Yang, RA Weinberg - Developmental cell, 2008 - cell.com
The epithelial-mesenchymal transition is a highly conserved cellular program that allows
polarized, immotile epithelial cells to convert to motile mesenchymal cells. This important …

Conversion of vascular endothelial cells into multipotent stem-like cells

D Medici, EM Shore, VY Lounev, FS Kaplan, R Kalluri… - Nature medicine, 2010 - nature.com
Mesenchymal stem cells can give rise to several cell types, but varying results depending on
isolation methods and tissue source have led to controversies about their usefulness in …

Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease

A von Gise, WT Pu - Circulation research, 2012 - Am Heart Assoc
Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and
developmentally plastic mesenchymal cells. All cells in the heart arise from one or more …