Notch signaling in development, tissue homeostasis, and disease
C Siebel, U Lendahl - Physiological reviews, 2017 - journals.physiology.org
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
MicroRNAs: roles in cardiovascular development and disease
Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
KR Cordes, NT Sheehy, MP White, EC Berry… - Nature, 2009 - nature.com
MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …
miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or …
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan - Cell, 2009 - cell.com
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
MicroRNA-133 controls cardiac hypertrophy
Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …
microRNAs in cardiovascular diseases: current knowledge and the road ahead
G Condorelli, MVG Latronico, E Cavarretta - Journal of the American …, 2014 - jacc.org
Over the last few years, the field of microribonucleic acid (miRNA) in cardiovascular biology
and disease has expanded at an incredible pace. miRNAs are themselves part of a larger …
and disease has expanded at an incredible pace. miRNAs are themselves part of a larger …
MicroRNA history: discovery, recent applications, and next frontiers
Since 1993, when the first small non-coding RNA was identified, our knowledge about
microRNAs has grown exponentially. In this review, we focus on the main progress in this …
microRNAs has grown exponentially. In this review, we focus on the main progress in this …
[HTML][HTML] Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
Y Zhao, JF Ransom, A Li, V Vedantham, M von Drehle… - Cell, 2007 - cell.com
MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …
the expression of proteins generated from messenger RNA transcripts. The in vivo …
Small non-coding RNAs in animal development
The modulation of gene expression by small non-coding RNAs is a recently discovered level
of gene regulation in animals and plants. In particular, microRNAs (miRNAs) and Piwi …
of gene regulation in animals and plants. In particular, microRNAs (miRNAs) and Piwi …
Gene regulatory networks in the evolution and development of the heart
EN Olson - Science, 2006 - science.org
The heart, an ancient organ and the first to form and function during embryogenesis, evolved
by the addition of new structures and functions to a primitive pump. Heart development is …
by the addition of new structures and functions to a primitive pump. Heart development is …