TGF-β signaling in control of cardiovascular function

MJ Goumans, P Ten Dijke - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

[HTML][HTML] TGF-β signaling in vascular biology and dysfunction

MJ Goumans, Z Liu, P Ten Dijke - Cell research, 2009 - nature.com
Transforming growth factor (TGF)-β family members are multifunctional cytokines that elicit
their effects on cells, including endothelial and mural cells, via specific type I and type II …

TGF-β family co-receptor function and signaling

J Nickel, P Ten Dijke, TD Mueller - Acta biochimica et …, 2018 - academic.oup.com
Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

The emerging role of alternative splicing in senescence and aging

M Deschenes, B Chabot - Aging cell, 2017 - Wiley Online Library
Deregulation of precursor mRNA splicing is associated with many illnesses and has been
linked to age‐related chronic diseases. Here we review recent progress documenting how …

Endoglin in angiogenesis and vascular diseases

P Ten Dijke, MJ Goumans, E Pardali - Angiogenesis, 2008 - Springer
Endoglin is a transmembrane auxillary receptor for transforming growth factor-β (TGF-β) that
is predominantly expressed on proliferating endothelial cells. Endoglin deficient mice die …

[HTML][HTML] The emerging role of TGF-β superfamily coreceptors in cancer

C Bernabeu, JM Lopez-Novoa, M Quintanilla - Biochimica et Biophysica …, 2009 - Elsevier
The transforming growth factor β (TGF-β) signaling pathway plays a key role in different
physiological processes such as development, cellular proliferation, extracellular matrix …

[HTML][HTML] Endoglin: beyond the endothelium

MJA Schoonderwoerd, MJTH Goumans… - Biomolecules, 2020 - mdpi.com
Endoglin, a type-III accessory receptor for the Transforming Growth Factor (TGF)-β
superfamily pathway, is known for its crucial role during angiogenesis. Extensive work has …

The physiological role of endoglin in the cardiovascular system

JM López-Novoa, C Bernabeu - American Journal of …, 2010 - journals.physiology.org
Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for
members of the transforming growth factor-β superfamily of proteins. A major role for …

[HTML][HTML] CD105 (endoglin)-negative murine mesenchymal stromal cells define a new multipotent subpopulation with distinct differentiation and immunomodulatory …

P Anderson, AB Carrillo-Gálvez, A García-Pérez… - PloS one, 2013 - journals.plos.org
Administration of in vitro expanded mesenchymal stromal cells (MSCs) represents a
promising therapy for regenerative medicine and autoimmunity. Both mouse and human …

Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours

E Fonsatti, HJM Nicolay, M Altomonte… - Cardiovascular …, 2010 - academic.oup.com
Endoglin/CD105 is well acknowledged as being the most reliable marker of proliferation of
endothelial cells, and it is overexpressed on tumour neovasculature. Our current knowledge …