Proteinase-activated receptors are a recently described, novel family of seven-
transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand …

The family of G protein‐coupled receptors (GPCRs) constitutes the largest class of signalling
receptors in the human genome, controlling vast physiological responses and are the target …

Because of the role of thrombin and platelets in myocardial infarction and other pathological
processes, identifying and blocking the receptors by which thrombin activates platelets has …

Platelets, activated by various agonists, produce microparticles (MP) from the plasma
membrane, which are released into the extracellular space. Although the mechanism of MP …

Although serine proteases are usually considered to act principally as degradative enzymes,
certain proteases are signaling molecules that specifically regulate cells by cleaving and …

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …

How does a protease act like a hormone to regulate cellular functions? The coagulation
protease thrombin (EC 3.4. 21.5) activates platelets and regulates the behavior of other cells …

Epithelia from many tissues express protease-activated receptors (PARs) that play a major
role in several different physiological processes. In this study, we examined their capacity to …

The activation of human platelets by α-thrombin is mediated at least in part by cleavage of
protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibα …

The four PAR family members are G protein coupled receptors that are normally activated by
proteolytic exposure of an occult tethered ligand. Three of the family members are thrombin …