The presence of human herpesvirus 6 in the brain in health and disease

G Santpere, M Telford, P Andrés-Benito, A Navarro… - Biomolecules, 2020 - mdpi.com
The human herpesvirus 6 (HHV-6)-A and-B are two dsDNA beta-herpesviruses infecting
almost the entire worldwide population. These viruses have been implicated in multiple …

The Role of Human Herpesvirus 6 Infection in Alzheimer's Disease Pathogenicity—A Theoretical Mosaic

C Romanescu, TG Schreiner, I Mukovozov - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative disorder generally affecting older adults, is
the most common form of dementia worldwide. The disease is marked by severe cognitive …

A reliable Epstein-Barr Virus classification based on phylogenomic and population analyses

L Zanella, I Riquelme, K Buchegger, M Abanto, C Ili… - Scientific reports, 2019 - nature.com
Abstract The Epstein-Barr virus (EBV) infects more than 90% of the human population,
playing a key role in the origin and progression of malignant and non-malignant diseases …

Evolutionary history of endogenous human herpesvirus 6 reflects human migration out of Africa

A Aswad, G Aimola, D Wight… - Molecular Biology …, 2021 - academic.oup.com
Human herpesvirus 6A and 6B (HHV-6) can integrate into the germline, and as a result,∼
70 million people harbor the genome of one of these viruses in every cell of their body. Until …

Comprehensive annotations of human herpesvirus 6A and 6B genomes reveal novel and conserved genomic features

Y Finkel, D Schmiedel, J Tai-Schmiedel, A Nachshon… - Elife, 2020 - elifesciences.org
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the
majority of the human population. They encompass large genomes and our understanding …

Endogenization and excision of human herpesvirus 6 in human genomes

X Liu, S Kosugi, R Koide, Y Kawamura, J Ito… - PLoS …, 2020 - journals.plos.org
Sequences homologous to human herpesvirus 6 (HHV-6) are integrated within the nuclear
genome of about 1% of humans, but it is not clear how this came about. It is also uncertain …

Fetal inheritance of chromosomally integrated human herpesvirus 6 predisposes the mother to pre-eclampsia

F Gaccioli, S Lager, MC de Goffau, U Sovio… - Nature …, 2020 - nature.com
Pre-eclampsia (typically characterized by new-onset hypertension and proteinuria in the
second half of pregnancy) represents a major determinant of the global burden of disease …

Mechanisms of viral persistence in the brain and therapeutic approaches

A Nath, TP Johnson - The FEBS Journal, 2022 - Wiley Online Library
There is growing recognition of the diversity of viruses that can infect the cells of the central
nervous system (CNS). While the majority of CNS infections are successfully cleared by the …

Latent human herpesvirus 6 is reactivated in CAR T cells

CA Lareau, Y Yin, K Maurer, KD Sandor, B Daniel… - Nature, 2023 - nature.com
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks
associated with the development of therapies from manipulated human cells are …

Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

ML Wood, CD Veal, R Neumann, NM Suárez, J Nichols… - Elife, 2021 - elifesciences.org
Human herpesviruses 6A and 6B (HHV-6A/6B) are ubiquitous pathogens that persist
lifelong in latent form and can cause severe conditions upon reactivation. They are spread …