[PDF][PDF] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
[PDF][PDF] From pharmacogenetics to pharmaco-omics: Milestones and future directions
The origins of pharmacogenetics date back to the 1950s, when it was established that inter-
individual differences in drug response are partially determined by genetic factors. Since …
individual differences in drug response are partially determined by genetic factors. Since …
Cross-ancestry investigation of venous thromboembolism genomic predictors
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …
environmental and genetic determinants. Recent VTE genome-wide association studies …
[PDF][PDF] A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis
Genomics-driven drug discovery is indispensable for accelerating the development of novel
therapeutic targets. However, the drug discovery framework based on evidence from …
therapeutic targets. However, the drug discovery framework based on evidence from …
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine
The integration of multiomics data with detailed phenotypic insights from electronic health
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
records marks a paradigm shift in biomedical research, offering unparalleled holistic views …
[PDF][PDF] Best practices for multi-ancestry, meta-analytic transcriptome-wide association studies: lessons from the Global Biobank Meta-analysis Initiative
Summary The Global Biobank Meta-analysis Initiative (GBMI), through its diversity, provides
a valuable opportunity to study population-wide and ancestry-specific genetic associations …
a valuable opportunity to study population-wide and ancestry-specific genetic associations …
Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia
Importance Hypertensive disorders of pregnancy (HDPs), including gestational hypertension
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …
Circadian protein expression patterns in healthy young adults
A Specht, G Kolosov, KLJ Cederberg, F Bueno… - Sleep Health, 2024 - Elsevier
Objectives To explore how the blood plasma proteome fluctuates across the 24-hour day
and identify a subset of proteins that show endogenous circadian rhythmicity. Methods …
and identify a subset of proteins that show endogenous circadian rhythmicity. Methods …
[PDF][PDF] Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure
The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …
Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins
Proteome-wide Mendelian randomization (MR) has emerged as a promising approach in
uncovering novel therapeutic targets. However, genetic colocalization analysis has revealed …
uncovering novel therapeutic targets. However, genetic colocalization analysis has revealed …