A reverse vaccinology approach to design an mRNA-based vaccine to provoke a robust immune response against HIV-1
There have been substantial advances in HIV research over the past three decades, but we
are still far from our goal of eliminating HIV-1 infection entirely. Numerous ever-evolving …
are still far from our goal of eliminating HIV-1 infection entirely. Numerous ever-evolving …
Designing a novel chimeric multi-epitope vaccine subunit against Staphylococcus argenteus through artificial intelligence approach integrating pan-genome analysis …
Staphylococcus argenteus is a newly identified pathogen that causes respiratory tract
infections, skin infections, such as cellulitis, abscesses, and impetigo, and currently, there is …
infections, skin infections, such as cellulitis, abscesses, and impetigo, and currently, there is …
Investigation of VEGF (rs 699947) polymorphism in the progression of Rheumatoid Arthritis (RA) and in-silico nanoparticle drug delivery of potential phytochemicals to …
Mutation in the VEGF gene disturbs the production of chondrocytes and angiogenesis which
are essential for cartilage health. Cytokines and chemokines produced by auto-activation of …
are essential for cartilage health. Cytokines and chemokines produced by auto-activation of …
Design and development of new inhibitors against breast cancer, Monkeypox and Marburg virus by modification of natural Fisetin via in silico and SAR studies
The natural Fisetin and its derivatives have been shown to have effective bioactivity and
strong pharmacological profile, which is continuously drawing the interest of therapeutic …
strong pharmacological profile, which is continuously drawing the interest of therapeutic …
[PDF][PDF] Revolutionizing treatment for toxic shock syndrome with engineered super chromones to combat antibiotic-resistant Staphylococcus aureus.
OBJECTIVE: Staphylococcus aureus-induced toxic shock syndrome (TSS) is a rare, but
potentially fatal disease with limited treatment options. The emergence of antibiotic-resistant …
potentially fatal disease with limited treatment options. The emergence of antibiotic-resistant …
[PDF][PDF] A pharmacophore screening approach of homeopathic phenols for a renovated design of fragment-optimized Bauhiniastatin-1 as a drug against acromegaly.
OBJECTIVE: Acromegaly is a fatal and chronic disease that is caused by the abnormal
secretion of growth hormone (GH) by the pituitary adenoma or pituitary tumor, resulting in an …
secretion of growth hormone (GH) by the pituitary adenoma or pituitary tumor, resulting in an …
Emerging Trends of Gold Nanostructures for Point-of-Care Biosensor-Based Detection of COVID-19
In 2019, a worldwide pandemic caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) emerged. SARS-CoV-2 is the deadly microorganism …
coronavirus 2 (SARS-CoV-2) emerged. SARS-CoV-2 is the deadly microorganism …
Bioinformatics approach for structure modeling, vaccine design, and molecular docking of Brucella candidate proteins BvrR, OMP25, and OMP31
Brucellosis is a zoonotic disease with significant economic and healthcare costs. Despite the
eradication efforts, the disease persists. Vaccines prevent disease in animals while …
eradication efforts, the disease persists. Vaccines prevent disease in animals while …
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
The zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its
high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug …
high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug …
Integrating 16S rRNA profiling and in-silico analysis for an epitope-based vaccine strategy against Achromobacter xylosoxidans infection
Achromobacter xylosoxidans is an aerobic, catalase-positive, non-pigment-forming, Gram-
negative, and motile bacterium. It potentially causes a wide range of human infections in …
negative, and motile bacterium. It potentially causes a wide range of human infections in …