Vaginal instillation of small-interfering RNA (siRNA) using liposomes has led to silencing of
endogenous genes in the genital tract and protection against challenge from infectious …

The pathogenesis of human immunodeficiency virus has long been thought to center on a
gradual depletion of CD4+ T cells, with an average of 100 cells lost per microliter of blood …

Understanding the initial events in the establishment of vaginal human immunodeficiency
virus type-1 (HIV-1) entry and infection has been hampered by the lack of appropriate …

HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope
(Env) glycoprotein with specific cell surface receptors. Protective antiviral antibodies …

Background In the absence of an effective vaccine, HIV continues to spread globally,
emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis …

To prevent sexually transmitted HIV, the most desirable active ingredients of microbicides
are antiretrovirals (ARVs) that directly target viral entry and avert infection at mucosal …

Human immunodeficiency virus-1 (HIV-1) infection currently requires lifelong therapy with
drugs that are used in combination to control viremia. The indole-3-glyoxamide 6 was …

Background Worldwide, vaginal transmission now accounts for more than half of newly
acquired HIV-1 infections. Despite the urgency to develop and implement novel approaches …

Chemokine receptors are found on cell surfaces and promote cellular migration by
chemotaxis. The CC chemokine receptor 5 (CCR5) is used by the human immunodeficiency …

Infection of target cells by HIV is a complex, multi-stage process involving attachment to host
cells and CD4 binding, coreceptor binding, and membrane fusion. Drugs that block HIV …