Non-invasive and minimally-invasive cerebral autoregulation assessment: a narrative review of techniques and implications for clinical research

AS Sainbhi, A Gomez, L Froese, T Slack… - Frontiers in …, 2022 - frontiersin.org
The process of cerebral vessels regulating constant cerebral blood flow over a wide range of
systemic arterial pressures is termed cerebral autoregulation (CA). Static and dynamic …

Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: a systematic review of the methodology

MH Olsen, CG Riberholt, J Mehlsen… - Journal of Cerebral …, 2022 - journals.sagepub.com
Cerebral autoregulation is a complex mechanism that serves to keep cerebral blood flow
relatively constant within a wide range of cerebral perfusion pressures. The mean flow index …

Autonomic dysfunction and associations with functional and neurophysiological outcome in moderate/severe traumatic brain injury: a scoping review

M Hasen, A Almojuela, FA Zeiler - Journal of neurotrauma, 2019 - liebertpub.com
The quantification and objective documentation of autonomic dysfunction in traumatic brain
injury (TBI) is neither well studied nor extensively validated. Most of the descriptions of …

Pressure autoregulation measurement techniques in adult traumatic brain injury, part I: a scoping review of intermittent/semi-intermittent methods

FA Zeiler, J Donnelly, L Calviello, DK Menon… - Journal of …, 2017 - liebertpub.com
The purpose of this study was to perform a systematic, scoping review of commonly
described intermittent/semi-intermittent autoregulation measurement techniques in adult …

Utility of transcranial doppler in moderate and severe traumatic brain injury: a narrative review of cerebral physiologic metrics

A Gomez, C Batson, L Froese, AS Sainbhi… - Journal of …, 2021 - liebertpub.com
Since its creation in the 1980s, transcranial Doppler (TCD) has provided a method of non-
invasively monitoring cerebral physiology and has become an invaluable tool in …

Early head-up mobilisation versus standard care for patients with severe acquired brain injury: a systematic review with meta-analysis and Trial Sequential Analysis

CG Riberholt, V Wagner, J Lindschou, C Gluud… - PLoS …, 2020 - journals.plos.org
Background There is increasing focus on earlier rehabilitation in patients with traumatic or
hypoxic brain injury or stroke. This systematic review evaluates the benefits and harms of …

Autonomic response to early head‐up tilt in patients with severe traumatic brain injury: Analysis from a randomized feasibility trial

MD Schultz, M Alstrup, MH Olsen… - Physiological …, 2023 - Wiley Online Library
Patients with severe traumatic brain injury (TBI) may have autonomic dysfunction, one
manifestation of which is orthostatic intolerance. This potentially impairs physical …

Diagnostic and prognostic performance of Mxa and transfer function analysis-based dynamic cerebral autoregulation metrics

MH Olsen, C Riberholt, RR Plovsing… - Journal of Cerebral …, 2022 - journals.sagepub.com
Dynamic cerebral autoregulation is often assessed by continuously recorded arterial blood
pressure (ABP) and transcranial Doppler-derived mean cerebral blood flow velocity followed …

Diffuse optical assessment of cerebral‐autoregulation in older adults stratified by cerebrovascular risk

AA Bahrani, W Kong, Y Shang, C Huang… - Journal of …, 2020 - Wiley Online Library
Diagnosis of cerebrovascular disease (CVD) at early stages is essential for preventing
sequential complications. CVD is often associated with abnormal cerebral microvasculature …

Myths and methodologies: Assessment of dynamic cerebral autoregulation by the mean flow index

MH Olsen, CG Riberholt, RMG Berg… - Experimental …, 2024 - Wiley Online Library
The mean flow index—usually referred to as Mx—has been used for assessing dynamic
cerebral autoregulation (dCA) for almost 30 years. However, concerns have arisen …