The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Diagnosis of neonatal sepsis: the role of inflammatory markers

J Eichberger, E Resch, B Resch - Frontiers in Pediatrics, 2022 - frontiersin.org
This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …

Understanding the role of the gut microbiome in brain development and its association with neurodevelopmental psychiatric disorders

S Dash, YA Syed, MR Khan - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The gut microbiome has a tremendous influence on human physiology, including the
nervous system. During fetal development, the initial colonization of the microbiome …

Maternal SARS-CoV-2, placental changes and brain injury in 2 neonates

M Benny, ES Bandstra, AG Saad… - …, 2023 - publications.aap.org
Long-term neurodevelopmental sequelae are a potential concern in neonates following in
utero exposure to severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) …

[HTML][HTML] Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury

N Gomez-Lopez, V Garcia-Flores, PY Chin… - JCI insight, 2021 - ncbi.nlm.nih.gov
Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …

Reliability of interleukin-6 alone and in combination for diagnosis of early onset neonatal sepsis: Systematic review

J Eichberger, B Resch - Frontiers in Pediatrics, 2022 - frontiersin.org
Neonatal sepsis is a major cause of morbidity and mortality in both preterm and term infants.
Early-onset neonatal sepsis (EONS) presents within the first 72 h of life. Diagnosis is difficult …

Meconium-stained amniotic fluid

DM Gallo, R Romero, M Bosco, F Gotsch… - American journal of …, 2023 - Elsevier
Green-stained amniotic fluid, often referred to as meconium-stained amniotic fluid, is present
in 5% to 20% of patients in labor and is considered an obstetric hazard. The condition has …

Adverse prenatal exposures and fetal brain development: insights from advanced fetal magnetic resonance imaging

J De Asis-Cruz, N Andescavage… - Biological Psychiatry …, 2022 - Elsevier
Converging evidence from clinical and preclinical studies suggests that fetal vulnerability to
adverse prenatal exposures increases the risk for neuropsychiatric diseases such as autism …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Perinatal infection, inflammation, preterm birth, and brain injury: A review with proposals for future investigations

JD Reiss, LS Peterson, SN Nesamoney, AL Chang… - Experimental …, 2022 - Elsevier
Preterm newborns are exposed to several risk factors for developing brain injury. Clinical
studies have suggested that the presence of intrauterine infection is a consistent risk factor …