Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

An overview of vaccine adjuvants: current evidence and future perspectives

A Facciolà, G Visalli, A Laganà, A Di Pietro - Vaccines, 2022 - mdpi.com
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …

Virus-like particles: Revolutionary platforms for developing vaccines against emerging infectious diseases

H Tariq, S Batool, S Asif, M Ali, BH Abbasi - Frontiers in microbiology, 2022 - frontiersin.org
Virus-like particles (VLPs) are nanostructures that possess diverse applications in
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …

Vaccine-like nanomedicine for cancer immunotherapy

Y Yi, M Yu, W Li, D Zhu, L Mei, M Ou - Journal of Controlled Release, 2023 - Elsevier
The successful clinical application of immune checkpoint blockade (ICB) and chimeric
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …

Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities

M Ghattas, G Dwivedi, M Lavertu, MG Alameh - Vaccines, 2021 - mdpi.com
Vaccination is a key component of public health policy with demonstrated cost-effective
benefits in protecting both human and animal populations. Vaccines can be manufactured …

Protein-based antigen presentation platforms for nanoparticle vaccines

B Nguyen, NH Tolia - npj Vaccines, 2021 - nature.com
Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …

Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

Potential applications of plant biotechnology against SARS-CoV-2

T Capell, RM Twyman, V Armario-Najera, JKC Ma… - Trends in plant …, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus
responsible for an ongoing human pandemic (COVID-19). There is a massive international …

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

R Sartorius, M Trovato, R Manco, L D'Apice… - npj Vaccines, 2021 - nature.com
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-
recognition receptors. They function as sensors of invading pathogens through recognition …

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

JS Chahal, OF Khan, CL Cooper… - Proceedings of the …, 2016 - National Acad Sciences
Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens …