Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function
Right ventricular (RV) structure and function influence the morbidity and mortality from
coronary artery disease (CAD), dilated cardiomyopathy (DCM), pulmonary hypertension and …
coronary artery disease (CAD), dilated cardiomyopathy (DCM), pulmonary hypertension and …
Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver
disease, a major cause of mortality. We conduct a meta-analysis of genome-wide …
disease, a major cause of mortality. We conduct a meta-analysis of genome-wide …
Population-specific causal disease effect sizes in functionally important regions impacted by selection
Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …
The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases
Background Interest in the interplay between host genetics and the gut microbiome in
complex human diseases is increasing, with prior evidence mainly being derived from …
complex human diseases is increasing, with prior evidence mainly being derived from …
[HTML][HTML] Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference
A Köttgen, E Cornec-Le Gall, J Halbritter, K Kiryluk… - Kidney international, 2022 - Elsevier
Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …
well as genes for complex kidney diseases that manifest in combination with environmental …
Single-cell chromatin accessibility identifies pancreatic islet cell type–and state-specific regulatory programs of diabetes risk
Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-
seq) creates new opportunities to dissect cell type–specific mechanisms of complex …
seq) creates new opportunities to dissect cell type–specific mechanisms of complex …
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
S Bell, AS Rigas, MK Magnusson… - Communications …, 2021 - nature.com
Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association …
health implications. We performed a meta-analysis of three genome-wide association …
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we
identify a common missense variant in the Mitochondrial Amidoxime Reducing Component …
identify a common missense variant in the Mitochondrial Amidoxime Reducing Component …
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
Background Coronary artery disease (CAD) remains the leading cause of mortality
worldwide despite enormous efforts devoted to its prevention and treatment. While many …
worldwide despite enormous efforts devoted to its prevention and treatment. While many …
A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …
medicine. Resources such as imputation reference panels that match the study population …