Human physiology is likely to have been selected for endurance physical activity. However,
modern humans have become largely sedentary, with physical activity becoming a leisure …

Chronic kidney disease (CKD) affects~ 10% of the global population, with considerable
ethnic differences in prevalence and aetiology. We assemble genome-wide association …

Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …

Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and
biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and …

Abstract Purpose of Review The strength of the relationship between diabetes, diabetic
retinopathy (DR), and glaucoma remains controversial. We review evidence supporting and …

Polygenic risk prediction is a widely investigated topic because of its promising clinical
applications. Genetic variants in functional regions of the genome are enriched for complex …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is
predicted to increase across the globe by~ 70% in the following decades. Understanding the …

The immune response is governed by a highly complex set of interactions among cells and
mediators. T cells may be rendered dysfunctional by the presence of high levels of antigen …